Intestinal cell cycle regulations. Interactions of cyclin D1, Cdk4, and p21Cip1.

Abstract

OBJECTIVE The p21Cip1 protein is a potent stoichiometric inhibitor of cyclin-dependent kinase activity, and p21Cip1 mRNA expression is localized to the nonproliferative compartment of the intestinal villus, suggesting an in vivo growth-inhibitory role in the gut. The authors determined whether nontransformed rat intestinal epithelial cells (IECs) underwent… (More)

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