Intestinal capacity of P-glycoprotein is higher in the juniper specialist, Neotoma stephensi, than the sympatric generalist, Neotoma albigula.

@article{Green2004IntestinalCO,
  title={Intestinal capacity of P-glycoprotein is higher in the juniper specialist, Neotoma stephensi, than the sympatric generalist, Neotoma albigula.},
  author={Adam K. Green and Shannon L. Haley and M. Denise Dearing and David M. Barnes and William H Karasov},
  journal={Comparative biochemistry and physiology. Part A, Molecular & integrative physiology},
  year={2004},
  volume={139 3},
  pages={325-33}
}
Permeability-glycoprotein (Pgp) is a membrane-bound, ATP-dependent, transport protein that excludes many cytotoxic compounds including plant metabolites and pollutants from the barrier epithelia of many tissues including the small intestine. We hypothesized that intestinal Pgp capacity would be higher in Neotoma stephensi, a specialist on Juniperus monosperma known to be high in plant toxins, than the sympatric generalist, Neotoma albigula, which consumes juniper in the field, but is unable to… CONTINUE READING
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Scaling of digestive efficiency with body mass in Neotoma

  • F. A. Smith
  • Funct. Ecol
  • 1995
Highly Influential
4 Excerpts

The hepatic microsomal enzymes of sea birds and their interaction with liposoluble pollutants

  • C. H. Walker, G. C. Knight
  • Aquat. Toxicol
  • 1981
Highly Influential
4 Excerpts

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