Intestinal calcium absorption: Molecular vitamin D mediated mechanisms

  title={Intestinal calcium absorption: Molecular vitamin D mediated mechanisms},
  author={R. Bouillon and S. van Cromphaut and G. Carmeliet},
  journal={Journal of Cellular Biochemistry},
  • R. Bouillon, S. van Cromphaut, G. Carmeliet
  • Published 2003
  • Chemistry, Medicine
  • Journal of Cellular Biochemistry
  • Rickets and hyperparathyroidism caused by a defective Vitamin D receptor (VDR) can be prevented in humans and animals by high calcium intake, suggesting that intestinal calcium absorption is critical for 1,25(OH)2 vitamin D [1,25‐(OH)2D3] action on calcium homeostasis. We assessed the rate of serum 45Ca accumulation within 10 min after oral gavage in two strains of VDR‐knock out (KO) mice (Leuven and Tokyo KO) and observed a threefold lower area under the curve in both KO‐strains. Moreover, we… CONTINUE READING
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