Intestinal barrier function

  title={Intestinal barrier function},
  author={Daniel C. Baumgart and Axel U Dignass},
  journal={Current Opinion in Clinical Nutrition and Metabolic Care},
  • D. BaumgartA. Dignass
  • Published 1 November 2002
  • Biology, Medicine
  • Current Opinion in Clinical Nutrition and Metabolic Care
Intestinal barrier function regulates transport and host defense mechanisms at the mucosal interface with the outside world. Transcellular and paracellular fluxes are tightly controlled by membrane pumps, ion channels and tight junctions, adapting permeability to physiological needs. Food and microbial antigens are under constant surveillance of the mucosal immune system. Tolerance against commensals and immunity against pathogens require intact antigen uptake, recognition, processing and… 

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