Intestinal barrier dysfunction and increased COX-2 gene expression in the gut of elderly rats with acute pancreatitis.

@article{Barbeiro2016IntestinalBD,
  title={Intestinal barrier dysfunction and increased COX-2 gene expression in the gut of elderly rats with acute pancreatitis.},
  author={Denise Frediani Barbeiro and M{\'a}rcia Kiyomi Koike and Ana Maria de Mendonça Coelho and Fabiano Pinheiro da Silva and Marcel Cerqueira C{\'e}sar Machado},
  journal={Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]},
  year={2016},
  volume={16 1},
  pages={52-6}
}
BACKGROUND/OBJECTIVES The clinical course of acute pancreatitis can vary from mild to severe. In its most severe manifestation, acute pancreatitis is associated with an exacerbated systemic inflammatory response and high mortality rates. The severe form of acute pancreatitis is more frequent in elderly patients than in young patients, but the mechanisms underlying this difference are still under investigation. METHODS Rats were divided into two groups as follows: Group 1, young rats; and… CONTINUE READING

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