Intestinal barrier disruption as a cause of mortality in combined radiation and burn injury.

@article{Carter2013IntestinalBD,
  title={Intestinal barrier disruption as a cause of mortality in combined radiation and burn injury.},
  author={Stewart R Carter and Anita Zahs and Jessica L. Palmer and Lu Wang and Luis Ram{\'i}rez and Richard L. Gamelli and Elizabeth J. Kovacs},
  journal={Shock},
  year={2013},
  volume={40 4},
  pages={281-9}
}
Nuclear disaster associated with combined radiation injury (CRI) and trauma or burns results in higher mortality than component injuries. Early death is caused by sequelae of gastrointestinal (GI) leakiness such as bacterial translocation and shock. We developed a murine model to characterize GI injury after CRI and determine the extent of barrier disruption. Animals received radiation (5.5 Gy) alone or with 15% total body surface area (TBSA) scald burn and were euthanized at 24, 48, and 72 h… CONTINUE READING
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