Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota.

  title={Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota.},
  author={Madhu S. Malo and Sayeda Nasrin Alam and Golam Mostafa and Skye J. Zeller and Paul V Johnson and Nasr Mohammad and Kathryn T. Chen and Angela K. Moss and Sundaram Ramasamy and A Faruqui and Sophie Hodin and Paulo S Mal{\'o} and F. Ebrahimi and Brishti Biswas and Sonoko Narisawa and J. L. Mill{\'a}n and H. Shaw Warren and Jeffrey B. Kaplan and Christopher L. Kitts and Elizabeth L. Hohmann and Richard Aaron Hodin},
  volume={59 11},
BACKGROUND AND AIMS The intestinal microbiota plays a critical role in maintaining human health; however, the mechanisms governing the normal homeostatic number and composition of these microbes are largely unknown. Previously it was shown that intestinal alkaline phosphatase (IAP), a small intestinal brush border enzyme, functions as a gut mucosal defence factor limiting the translocation of gut bacteria to mesenteric lymph nodes. In this study the role of IAP in the preservation of the normal… CONTINUE READING
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