Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition.

  title={Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition.},
  author={Ross F Goldberg and William Gerald Austen and Xiaobo Zhang and Gitonga Munene and Golam Mostafa and Shaluk Biswas and M Terrance McCormack and Kyle R. Eberlin and John T. Nguyen and Hamit Soner Tatlidede and H. Shaw Warren and Sonoko Narisawa and J. L. Mill{\'a}n and Richard Aaron Hodin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={105 9},
Under conditions of starvation and disease, the gut barrier becomes impaired, and trophic feeding to prevent gut mucosal atrophy has become a standard treatment of critically ill patients. However, the mechanisms responsible for the beneficial effects of enteral nutrition have remained a mystery. Using in vitro and in vivo models, we demonstrate that the brush-border enzyme, intestinal alkaline phosphatase (IAP), has the ability to detoxify lipopolysaccharide and prevent bacterial invasion… CONTINUE READING
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