Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis.

@article{Ramasamy2010IntestinalAP,
  title={Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis.},
  author={S. Ramasamy and Deanna D. Nguyen and Michelle A. Eston and Sayeda Nasrin Alam and Angela K. Moss and Farzad Ebrahimi and Brishti Biswas and Golam Mostafa and Kathryn T. Chen and Kanakaraju Kaliannan and Halim Yammine and Sonoko Narisawa and Jos{\'e} Luis Mill{\'a}n and Howland Shaw Warren and Elizabeth L. Hohmann and Emiko Mizoguchi and Hans-Christian Reinecker and Atul K. Bhan and Scott B Snapper and Madhu S. Malo and Richard A. Hodin},
  journal={Inflammatory bowel diseases},
  year={2010},
  volume={17 2},
  pages={
          532-42
        }
}
BACKGROUND The brush border enzyme intestinal alkaline phosphatase (IAP) functions as a gut mucosal defense factor and is protective against dextran sulfate sodium (DSS)-induced acute injury in rats. The present study evaluated the potential therapeutic role for orally administered calf IAP (cIAP) in two independent mouse models of chronic colitis: 1) DSS-induced chronic colitis, and 2) chronic spontaneous colitis in Wiskott-Aldrich Syndrome protein (WASP)-deficient (knockout) mice that is… CONTINUE READING

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The Role of Intestinal Alkaline Phosphatase in Inflammatory Disorders of Gastrointestinal Tract

  • Mediators of inflammation
  • 2017
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CITES BACKGROUND & METHODS
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