Intestinal absorption of luteolin and luteolin 7‐O‐β‐glucoside in rats and humans

  title={Intestinal absorption of luteolin and luteolin 7‐O‐β‐glucoside in rats and humans},
  author={K. Shimoi and H. Okada and M. Furugori and T. Goda and S. Takase and M. Suzuki and Y. Hara and H. Yamamoto and N. Kinae},
  journal={FEBS Letters},
  • K. Shimoi, H. Okada, +6 authors N. Kinae
  • Published 1998
  • Chemistry, Medicine
  • FEBS Letters
  • In this study, we investigated the intestinal absorption of luteolin and luteolin 7‐O‐β‐glucoside in rats by HPLC. The absorption analysis using rat everted small intestine demonstrated that luteolin was converted to glucuronides during passing through the intestinal mucosa and that luteolin 7‐O‐β‐glucoside was absorbed after hydrolysis to luteolin. Free luteolin, its conjugates and methylated conjugates were present in rat plasma after dosing. This suggests that some luteolin can escape the… CONTINUE READING
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