Intestinal absorption of luteolin and luteolin 7‐O‐β‐glucoside in rats and humans

@article{Shimoi1998IntestinalAO,
  title={Intestinal absorption of luteolin and luteolin 7‐O‐β‐glucoside in rats and humans},
  author={K. Shimoi and H. Okada and M. Furugori and T. Goda and S. Takase and M. Suzuki and Y. Hara and H. Yamamoto and N. Kinae},
  journal={FEBS Letters},
  year={1998},
  volume={438}
}
  • K. Shimoi, H. Okada, +6 authors N. Kinae
  • Published 1998
  • Chemistry, Medicine
  • FEBS Letters
  • In this study, we investigated the intestinal absorption of luteolin and luteolin 7‐O‐β‐glucoside in rats by HPLC. The absorption analysis using rat everted small intestine demonstrated that luteolin was converted to glucuronides during passing through the intestinal mucosa and that luteolin 7‐O‐β‐glucoside was absorbed after hydrolysis to luteolin. Free luteolin, its conjugates and methylated conjugates were present in rat plasma after dosing. This suggests that some luteolin can escape the… CONTINUE READING
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    References

    SHOWING 1-10 OF 30 REFERENCES
    In vivo and in vitro glucuronidation of the flavonoid diosmetin in rats.
    • 79
    Absorption and excretion of the soy isoflavone genistein in rats.
    • 177
    • PDF
    Quercetin metabolites in plasma of rats fed diets containing rutin or quercetin.
    • 288