Intestinal absorption and postabsorptive metabolism of linoleic acid in rats with short-term bile duct ligation.

@article{Minich2000IntestinalAA,
  title={Intestinal absorption and postabsorptive metabolism of linoleic acid in rats with short-term bile duct ligation.},
  author={Deanna M Minich and Rick Havinga and Frans Stellaard and Roel J Vonk and Fred Kuipers and Henkjan J. Verkade},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2000},
  volume={279 6},
  pages={G1242-8}
}
We investigated in bile duct-ligated (BDL) and sham-operated control rats whether the frequent presence of essential fatty acid deficiency in cholestatic liver disease could be related to linoleic acid malabsorption, altered linoleic acid metabolism, or both. In plasma of BDL rats, the triene-to-tetraene ratio, a biochemical marker for essential fatty acid deficiency, was increased compared with controls (0.024 +/- 0.004 vs. 0.013 +/- 0.001; P < 0.05). Net and percentage of dietary linoleic… CONTINUE READING

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