Intestinal T Cell Responses to Cereal Proteins in Celiac Disease

  title={Intestinal T Cell Responses to Cereal Proteins in Celiac Disease},
  author={Christopher Kilmartin and Herbert Wieser and MB PhDM.Abuzakouk and Jacinta Kelly and Jessica Jackson and Conleth Feighery},
  journal={Digestive Diseases and Sciences},
Celiac disease is caused by sensitivity to wheat gluten in genetically susceptible individuals. The etiological role of the other wheat-related cereals, barley, rye, and oats, is still debated. In order to investigate this issue further, in this study we examined the immune response of celiac mucosal T cell lines to fractions from all four cereals. Cell stimulation was assessed by measuring proliferation (employing 3H-thymidine incorporation) or cytokine (IL-2, IFN-γ) production. All five T… CONTINUE READING
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