Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation.

@article{Wang2016IntestinalRL,
  title={Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation.},
  author={Lirui Wang and Derrick E. Fouts and Peter St{\"a}rkel and Phillipp Hartmann and Peng Chen and Cristina Llorente and Jessica DePew and Kelvin J. Moncera and Samuel B. Ho and David Brenner and Lora V Hooper and Bernd E. Schnabl},
  journal={Cell host & microbe},
  year={2016},
  volume={19 2},
  pages={227-39}
}
Approximately half of all deaths from liver cirrhosis, the tenth leading cause of mortality in the United States, are related to alcohol use. Chronic alcohol consumption is accompanied by intestinal dysbiosis and bacterial overgrowth, yet little is known about the factors that alter the microbial composition or their contribution to liver disease. We previously associated chronic alcohol consumption with lower intestinal levels of the antimicrobial-regenerating islet-derived (REG)-3 lectins… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 65 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

Similar Papers

Loading similar papers…