Intestinal Peptide Transport Systems and Oral Drug Availability

  title={Intestinal Peptide Transport Systems and Oral Drug Availability},
  author={Cheng Yong Yang and Anne H. Dantzig and Charles Pidgeon},
  journal={Pharmaceutical Research},
The intestinal peptide transport system has broad substrate specificities. In addition to its physiological function of absorbing di- and tripeptides resulting from the digestion of dietary proteins, this transport system also absorbs some orally administered peptidomimetic drugs, including β-lactam antibiotics, angiotensin converting enzyme inhibitors, renin inhibitors, bestatin, thrombin inhibitors, and thyrotropin-releasing hormone and its analogues. There have been several studies on the… CONTINUE READING


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