Intestinal Microbiota Promotes Psoriasis-Like Skin Inflammation by Enhancing Th17 Response

  title={Intestinal Microbiota Promotes Psoriasis-Like Skin Inflammation by Enhancing Th17 Response},
  author={Zuzana Z{\'a}kostelsk{\'a} and Jana M{\'a}lkov{\'a} and Kl{\'a}ra Klime{\vs}ov{\'a} and Pavel Rossmann and Michaela Hornov{\'a} and Iva Novos{\'a}dov{\'a} and Zuzana Stehl{\'i}kov{\'a} and Martin Kostov{\vc}{\'i}k and Tom{\'a}{\vs} Hudcovic and Renata {\vS}těp{\'a}nkov{\'a} and Katerina Juzlova and Jana Hercogov{\'a} and Helena Tlaskalova-Hogenova and Miloslav Kverka},
  booktitle={PloS one},
Psoriasis is a chronic inflammatory skin disease in which Th17 cells play a crucial role. Since indigenous gut microbiota influences the development and reactivity of immune cells, we analyzed the link among microbiota, T cells and the formation of psoriatic lesions in the imiquimod-induced murine model of psoriasis. To explore the role of microbiota, we induced skin inflammation in germ-free (GF), broad-spectrum antibiotic (ATB)-treated or conventional (CV) BALB/c and C57BL/6 mice. We found… CONTINUE READING
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