Intestinal Inflammation and Mucosal Barrier Function

  title={Intestinal Inflammation and Mucosal Barrier Function},
  author={F. S{\'a}nchez de Medina and I. Romero-Calvo and Cristina Mascaraque and O. Mart{\'i}nez-Augustin},
  journal={Inflammatory Bowel Diseases},
  • F. Sánchez de Medina, I. Romero-Calvo, +1 author O. Martínez-Augustin
  • Published 2014
  • Biology, Medicine
  • Inflammatory Bowel Diseases
  • Abstract:Intestinal mucosal barrier function is the capacity of the intestine to provide adequate containment of luminal microorganisms and molecules while preserving the ability to absorb nutrients. The central element is the epithelial layer, which physically separates the lumen and the internal milieu and is in charge of vectorial transport of ions, nutrients, and other substances. The secretion of mucus-forming mucins, sIgA, and antimicrobial peptides reinforces the mucosal barrier on the… CONTINUE READING
    122 Citations
    Nutritional Keys for Intestinal Barrier Modulation
    • 70
    • PDF
    Intestinal barrier integrity and inflammatory bowel disease: Stem cell‐based approaches to regenerate the barrier
    • 20
    The role of barrier function, autophagy, and cytokines in maintaining intestinal homeostasis.
    • 30
    • Highly Influenced
    Microbiota-host interplay at the gut epithelial level, health and nutrition
    • 29
    Food Derived Bioactive Peptides and Intestinal Barrier Function
    • 51
    • PDF
    Phytochemicals and inflammatory bowel disease: a review
    • 9


    Regulation of intestinal epithelial permeability by tight junctions
    • T. Suzuki
    • Biology, Medicine
    • Cellular and Molecular Life Sciences
    • 2012
    • 532
    • Highly Influential
    • PDF
    Modulation of intestinal barrier by intestinal microbiota: pathological and therapeutic implications.
    • 166
    Epithelial Cell-Intrinsic Notch Signaling Plays an Essential Role in the Maintenance of Gut Immune Homeostasis
    • 54
    • PDF
    The Role of Macrophages and Dendritic Cells in the Initiation of Inflammation in IBD
    • 125
    Wound healing of intestinal epithelial cells.
    • 172
    The role of pattern recognition receptors in intestinal inflammation
    • 123
    • Highly Influential
    A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide
    • 94
    • PDF
    The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine
    • 845
    • PDF
    Epithelial NEMO links innate immunity to chronic intestinal inflammation
    • 936
    • PDF