Intestinal Inflammation and Mucosal Barrier Function

  title={Intestinal Inflammation and Mucosal Barrier Function},
  author={F. S{\'a}nchez de Medina and I. Romero-Calvo and Cristina Mascaraque and O. Mart{\'i}nez-Augustin},
  journal={Inflammatory Bowel Diseases},
  • F. Sánchez de Medina, I. Romero-Calvo, +1 author O. Martínez-Augustin
  • Published 2014
  • Biology, Medicine
  • Inflammatory Bowel Diseases
  • Abstract:Intestinal mucosal barrier function is the capacity of the intestine to provide adequate containment of luminal microorganisms and molecules while preserving the ability to absorb nutrients. The central element is the epithelial layer, which physically separates the lumen and the internal milieu and is in charge of vectorial transport of ions, nutrients, and other substances. The secretion of mucus-forming mucins, sIgA, and antimicrobial peptides reinforces the mucosal barrier on the… CONTINUE READING
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