Intestinal IgA synthesis: regulation of front-line body defences

  title={Intestinal IgA synthesis: regulation of front-line body defences},
  author={S. Fagarasan and T. Honjo},
  journal={Nature Reviews Immunology},
  • S. Fagarasan, T. Honjo
  • Published 2003
  • Medicine, Biology
  • Nature Reviews Immunology
  • Immunoglobulin A is the most abundant immunoglobulin isotype in mucosal secretions. In this review, we summarize recent advances in our understanding of the sites, mechanisms and functions of intestinal IgA synthesis in mice. On the basis of these recent findings, we propose an updated model for the induction and regulation of IgA responses in the gut. In addition, we discuss new insights into the role of IgA in the maintenance of gut homeostasis and into the reciprocal interactions between gut… CONTINUE READING

    Figures and Topics from this paper.

    Paper Mentions

    Regulation of intestinal homeostasis by dendritic cells
    • 59
    • Highly Influenced
    A gas governing mucosal immunity.
    • 1
    Is the role of IgA in local immunity completely known?
    • 13
    The biology of intestinal immunoglobulin A responses.
    • 442
    The regulation of IgA class switching
    • 492
    • PDF


    Publications referenced by this paper.
    Influences of microbiota on intestinal immune system development.
    • 710
    • PDF
    Handbook of mucosal immunology
    • 573