Intestinal IgA synthesis: regulation of front-line body defences

@article{Fagarasan2003IntestinalIS,
  title={Intestinal IgA synthesis: regulation of front-line body defences},
  author={Sidonia Fagarasan and Tasuku Honjo},
  journal={Nature Reviews Immunology},
  year={2003},
  volume={3},
  pages={63-72}
}
Immunoglobulin A is the most abundant immunoglobulin isotype in mucosal secretions. In this review, we summarize recent advances in our understanding of the sites, mechanisms and functions of intestinal IgA synthesis in mice. On the basis of these recent findings, we propose an updated model for the induction and regulation of IgA responses in the gut. In addition, we discuss new insights into the role of IgA in the maintenance of gut homeostasis and into the reciprocal interactions between gut… 
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515 Citations
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515 Citations

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This review outlines the roles of the commensal flora, epithelial layer, and GALT in mucosal homeostasis and inflammatory conditions and highlights recent progress in understanding how DCs are involved in IgA synthesis in the gut.
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IgA antibodies belong to the most important humoral immune factors present on mucosal surfaces and may explain how the intestinal immune system is able to accommodate a wide range of microbes that have evolved a wide variety of intestinal lifestyles.
A gas governing mucosal immunity.
Intestinal IgA synthesis: a primitive form of adaptive immunity that regulates microbial communities in the gut.
  • S. Fagarasan
  • Biology
    Current topics in microbiology and immunology
  • 2006
TLDR
This chapter attempts to discuss the mechanisms that underlie this reciprocity and emphasize the key role of mucosal IgA in maintenance of an appropriate segmental distribution of microbiota, which is necessary for immune homeostasis.
Regulation and Function of Mucosal IgA and IgD
Diversified IgA-Bacteria Interaction in Gut Homeostasis.
TLDR
This chapter will review current understandings for the function of gut IgA in regulating commensal microbiota and suggest that multiple factors may be involved in the mechanisms of IgA-bacteria interactions.
Structure and Function of IgA
Biology of Gut Immunoglobulins
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