Intestinal Excretion of Unconjugated Bilirubin in Man and Rats with Inherited Unconjugated Hyperbilirubinemia

@article{Kotal1997IntestinalEO,
  title={Intestinal Excretion of Unconjugated Bilirubin in Man and Rats with Inherited Unconjugated Hyperbilirubinemia},
  author={Petr Kotal and Crista N Van Der Veere and Maarten Sinaasappel and Ronald Oude Elferink and Libor V{\'i}tek and Marie Brodanov{\'a} and Peter L. M. Jansen and Johan M J Fevery},
  journal={Pediatric Research},
  year={1997},
  volume={42},
  pages={195-200}
}
Patients with Crigler-Najjar syndrome and Gunn rats cannot form bilirubin glucuronides owing to a lack of bilirubin UDP-glucuronosyltransferase activity. Because increased serum and tissue bilirubin levels remain constant, an alternative excretory route has to substitute for this deficiency. Gunn rats excrete in bile only 2-13% of the bilirubins eliminated in Wistar rats. In contrast, the biliary excretion rate of urobilinogen in Gunn and Wistar rats is comparable. The sum of bilirubins and… CONTINUE READING

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