Intestinal Epithelial Serum Amyloid A Modulates Bacterial Growth In Vitro and Pro-Inflammatory Responses in Mouse Experimental Colitis

@inproceedings{Eckhardt2010IntestinalES,
  title={Intestinal Epithelial Serum Amyloid A Modulates Bacterial Growth In Vitro and Pro-Inflammatory Responses in Mouse Experimental Colitis},
  author={Erik RM Eckhardt and Jassir Witta and Jian Quan Zhong and Razvan I. Arsenescu and Violeta Arsenescu and Yu Wang and Sarbani Ghoshal and Marcielle de Beer and Frederick C. de Beer and Willem J. S. de Villiers},
  booktitle={BMC gastroenterology},
  year={2010}
}
BACKGROUND Serum Amyloid A (SAA) is a major acute phase protein of unknown function. SAA is mostly expressed in the liver, but also in other tissues including the intestinal epithelium. SAA reportedly has anti-bacterial effects, and because inflammatory bowel diseases (IBD) result from a breakdown in homeostatic interactions between intestinal epithelia and bacteria, we hypothesized that SAA is protective during experimental colitis. METHODS Intestinal SAA expression was measured in mouse and… CONTINUE READING
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