Intestinal DGAT1 deficiency reduces postprandial triglyceride and retinyl ester excursions by inhibiting chylomicron secretion and delaying gastric emptying

@inproceedings{Ables2012IntestinalDD,
  title={Intestinal DGAT1 deficiency reduces postprandial triglyceride and retinyl
ester excursions by inhibiting chylomicron secretion and delaying gastric
emptying},
  author={Gene P. Ables and Kryscilla Jian Zhang Yang and Silke Vogel and Antonio Hern{\'a}ndez-Ono and Shuiqing Yu and Jason J. Yuen and Susan Birtles and Linda K. Buckett and Andrew V. Turnbull and Ira J Goldberg and William S. Blaner and L Huang and Henry N. Ginsberg},
  booktitle={Journal of lipid research},
  year={2012}
}
Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 catalyzes the final step of triglyceride (TG) synthesis. We show that acute administration of a DGAT1 inhibitor (DGAT1i) by oral gavage or genetic deletion of intestinal Dgat1 (intestine-Dgat1(-/-)) markedly reduced postprandial plasma TG and retinyl ester excursions by inhibiting chylomicron secretion in mice. Loss of DGAT1 activity did not affect the efficiency of retinol esterification, but it did reduce TG and retinoid accumulation in the… CONTINUE READING

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