Intestinal Colonization of IL-2 Deficient Mice with Non-Colitogenic B. vulgatus Prevents DC Maturation and T-Cell Polarization

Abstract

BACKGROUND IL-2 deficient (IL-2(-/-)) mice mono-colonized with E. coli mpk develop colitis whereas IL-2(-/-)-mice mono-colonized with B. vulgatus mpk do not and are even protected from E. coli mpk induced colitis. METHODOLOGY/PRINCIPAL FINDINGS We investigated if mono-colonization with E. coli mpk or B. vulgatus mpk differentially modulates distribution… (More)
DOI: 10.1371/journal.pone.0002376

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