Intestinal CX3C chemokine receptor 1(high) (CX3CR1(high)) myeloid cells prevent T-cell-dependent colitis.

  title={Intestinal CX3C chemokine receptor 1(high) (CX3CR1(high)) myeloid cells prevent T-cell-dependent colitis.},
  author={Hisako Kayama and Yoshiyasu Ueda and Yukihisa Sawa and Seong Gyu Jeon and Ji Su Ma and Ryu Okumura and Atsuko Kubo and Masaru Ishii and Taku Okazaki and Masaaki Murakami and Masahiro Yamamoto and H. Yagita and Kiyoshi Takeda},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 13},
Adequate activation of CD4(+) T lymphocytes is essential for host defense against invading pathogens; however, exaggerated activity of effector CD4(+) T cells induces tissue damage, leading to inflammatory disorders such as inflammatory bowel diseases. Several unique subsets of intestinal innate immune cells have been identified. However, the direct involvement of innate immune cell subsets in the suppression of T-cell-dependent intestinal inflammation is poorly understood. Here, we report that… CONTINUE READING
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What are CX 3 CR 1 + mononuclear cells in the intestinal mucosa ?

  • CL Scott, AM Aumeunier, AM Mowat
  • Gut Microbes
  • 2011

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