Intestinal CCL11 and eosinophilic inflammation is regulated by myeloid cell-specific RelA/p65 in mice.

@article{Waddell2013IntestinalCA,
  title={Intestinal CCL11 and eosinophilic inflammation is regulated by myeloid cell-specific RelA/p65 in mice.},
  author={Amanda Waddell and Richard Ahrens and Yi-Ting Tsai and Joseph D. Sherrill and Lee A. Denson and Kris A. Steinbrecher and Simon P Hogan},
  journal={Journal of immunology},
  year={2013},
  volume={190 9},
  pages={4773-85}
}
In inflammatory bowel diseases (IBDs), particularly ulcerative colitis, intestinal macrophages (MΦs), eosinophils, and the eosinophil-selective chemokine CCL11, have been associated with disease pathogenesis. MΦs, a source of CCL11, have been reported to be of a mixed classical (NF-κB-mediated) and alternatively activated (STAT-6-mediated) phenotype. The importance of NF-κB and STAT-6 pathways to the intestinal MΦ/CCL11 response and eosinophilic inflammation in the histopathology of… CONTINUE READING
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