Intestinal Brush Border Assembly Driven by Protocadherin-Based Intermicrovillar Adhesion

@article{Crawley2014IntestinalBB,
  title={Intestinal Brush Border Assembly Driven by Protocadherin-Based Intermicrovillar Adhesion},
  author={Scott William Crawley and David A. Shifrin and Nathan E Grega-Larson and Russell E. McConnell and Andrew E. Benesh and Suli Mao and Yuxi Zheng and Qing Zheng and Ki Taek Nam and Bryan A. Millis and Bechara Kachar and Matthew J. Tyska},
  journal={Cell},
  year={2014},
  volume={157},
  pages={433-446}
}
Transporting epithelial cells build apical microvilli to increase membrane surface area and enhance absorptive capacity. The intestinal brush border provides an elaborate example with tightly packed microvilli that function in nutrient absorption and host defense. Although the brush border is essential for physiological homeostasis, its assembly is poorly understood. We found that brush border assembly is driven by the formation of Ca(2+)-dependent adhesion links between adjacent microvilli… CONTINUE READING