Intestinal Barrier Function and Secretion in Methotrexate-Induced Rat Intestinal Mucositis

  title={Intestinal Barrier Function and Secretion in Methotrexate-Induced Rat Intestinal Mucositis},
  author={Benedito A. Carneiro-Filho and Ila F. N. Lima and Diego Ara{\'u}jo and Maria Luzete Costa Cavalcante and Graça H P Carvalho and Gerly Anne C. Brito and Vilma Lima and Sandra Maria Nunes Monteiro and Filipe Santos and Ronaldo Albuquerque Ribeiro and A A M Lima},
  journal={Digestive Diseases and Sciences},
Chemotherapy-induced mucositis is an important dose-limiting and costly side effect for which there is no definitive prophylaxis or treatment. This is due in part to the lack of understanding of its pathophysiology and impact on intestinal function. The objectives of this study were to investigate the small intestine barrier function and electrolyte and water transport in an experimental model of methotrexate-induced mucositis, and to correlate these alterations with histological damage. Wistar… 

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