Intestinal Autophagy Improves Healthspan and Longevity in C. elegans during Dietary Restriction

@inproceedings{Gelino2016IntestinalAI,
  title={Intestinal Autophagy Improves Healthspan and Longevity in C. elegans during Dietary Restriction},
  author={Sara Gelino and Jessica Chang and Caroline Kumsta and Xingyu She and Andrew J Davis and Christian Nguyen and Siler H. Panowski and Malene Hansen},
  booktitle={PLoS genetics},
  year={2016}
}
Dietary restriction (DR) is a dietary regimen that extends lifespan in many organisms. One mechanism contributing to the conserved effect of DR on longevity is the cellular recycling process autophagy, which is induced in response to nutrient scarcity and increases sequestration of cytosolic material into double-membrane autophagosomes for degradation in the lysosome. Although autophagy plays a direct role in DR-mediated lifespan extension in the nematode Caenorhabditis elegans, the… CONTINUE READING
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e1006135

  • S Gelino, JT Chang, +5 authors 127 Longevity in C. elegans during Dietary Restriction Genet
  • doi: 10.1371/journal.pgen.1006135 PMID: 27414651…
  • 2016

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