Intervertebral disk repair by protein, gene, or cell injection: a framework for rehabilitation-focused biologics in the spine.

@article{Zhang2011IntervertebralDR,
  title={Intervertebral disk repair by protein, gene, or cell injection: a framework for rehabilitation-focused biologics in the spine.},
  author={Yejia Zhang and Ana V. Chee and Eugene J-M A Thonar and Howard S. An},
  journal={PM & R : the journal of injury, function, and rehabilitation},
  year={2011},
  volume={3 6 Suppl 1},
  pages={S88-94}
}
Low back pain carries an enormous socioeconomic burden. Current treatment modalities for symptomatic intervertebral disk (IVD) degeneration have limited and often inconsistent clinical benefits. Novel approaches with the potential to halt or even reverse disk degeneration and restore physiologic disk function, such as biological treatments, are therefore very attractive. The following barriers are impeding the development of successful therapeutic interventions: (1) the biology and… CONTINUE READING