Intervertebral disc cell death is dependent on the magnitude and duration of spinal loading.

@article{Lotz2000IntervertebralDC,
  title={Intervertebral disc cell death is dependent on the magnitude and duration of spinal loading.},
  author={Jeffrey C. Lotz and Jennie R. Chin},
  journal={Spine},
  year={2000},
  volume={25 12},
  pages={1477-83}
}
STUDY DESIGN An in vivo study of the toxic consequences of static compressive stress on the intervertebral disc. OBJECTIVES To determine whether disc cell death is correlated with the magnitude and duration of spinal compressive loading. SUMMARY OF BACKGROUND DATA Static compression in vivo has been demonstrated to induce cell death. Cell death, in turn, has been associated with disc degeneration in humans. There are currently no tolerance criteria for the intervertebral disc that combine… CONTINUE READING

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