Interventions to slow cardiovascular aging: Dietary restriction, drugs and novel molecules

  title={Interventions to slow cardiovascular aging: Dietary restriction, drugs and novel molecules},
  author={Christian Heiss and Ioakim Spyridopoulos and Judith Haendeler},
  journal={Experimental Gerontology},

Protective Effects of Curcumin in Cardiovascular Diseases—Impact on Oxidative Stress and Mitochondria

Curcumin as a nutraceutical could hold promise in the prevention of CVDs, but more standardized clinical trials are required to fully unravel its potential.

Nutrients and Pathways that Regulate Health Span and Life Span

A summary of the main molecular mechanisms by which different nutritional conditions, i.e., specific nutrient abundance or restriction, may affect health span and life span is provided.

The aging heart.

This review outlines the key molecular pathways and cellular processes that underlie the phenotypic changes in the heart and vasculature that accompany aging and highlights the factors known to accelerate and attenuate the intrinsic aging of the heart.

Does eating less make you live longer and better? An update on calorie restriction

This work concisely overviewed the recent results of CR treatment on humans, provided an update on the molecular mechanisms involved by CR and the effects on some of the age-associated cellular markers, and reviewed a number of tested CR mimetics.

One-year Mediterranean diet promotes epigenetic rejuvenation with country- and sex-specific effects: a pilot study from the NU-AGE project

It is suggested that Mediterranean diet can promote epigenetic rejuvenation but with country-, sex-, and individual-specific effects, thus highlighting the need for a personalized approach to nutritional interventions.

Circulating Anthocyanin Metabolites Mediate Vascular Benefits of Blueberries: Insights From Randomized Controlled Trials, Metabolomics, and Nutrigenomics.

The results identify anthocyanin metabolites as major mediators of vascular bioactivities of blueberries and changes of cellular gene programs and pathway enrichment analysis revealed significantly modulated biological processes involved in cell adhesion, migration, immune response, and cell differentiation.

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology.

It is expected that rigorous translational research of the ANG II signaling pathways including those in large animals and humans will contribute to establishing effective new therapies against various diseases.



Caloric restriction in humans: impact on physiological, psychological, and behavioral outcomes.

The first completed clinical studies that have investigated the effects of controlled, high-quality energy-restricted diets on both biomarkers of longevity and on the development of chronic diseases related to age in humans are investigated.

Manipulation of health span and function by dietary caloric restriction mimetics

The current status of the field of CR mimetics is reviewed, with particular focus on recent developments, the most practical relevance and applicability for potential consumers, and new strategies for the future.

Interventions to Slow Aging in Humans: Are We Ready?

There was consensus that there is sufficient evidence that aging interventions will delay and prevent disease onset for many chronic conditions of adult and old age and their potential to be safe and effective in extending human healthspan.

Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial

CF intake reverses age-related burden of cardiovascular risk in healthy elderly, highlighting the potential of dietary flavanols to maintain cardiovascular health.

AMPK activation: a therapeutic target for type 2 diabetes?

The regulation of the AMPK pathway and its role in type 2 diabetes, some of the known AMPK activators and their mechanisms of action, and the potential for future improvements in targeting AMPK for the treatment of T2D are reviewed.

SRT1720 improves survival and healthspan of obese mice

It is shown that SRT1720, a synthetic compound identified for its ability to activate Sirt1 in vitro, extends both mean and maximum lifespan of adult mice fed a high-fat diet and demonstrates for the first time the feasibility of designing novel molecules that are safe and effective in promoting longevity and preventing multiple age-related diseases in mammals.

Metformin improves healthspan and lifespan in mice

It is shown that long-term treatment with metformin starting at middle age extends healthspan and lifespan in male mice, while a higher dose (1% w/w) was toxic.