Interventions to slow cardiovascular aging: Dietary restriction, drugs and novel molecules

@article{Heiss2018InterventionsTS,
  title={Interventions to slow cardiovascular aging: Dietary restriction, drugs and novel molecules},
  author={Christian Heiss and Ioakim Spyridopoulos and Judith Haendeler},
  journal={Experimental Gerontology},
  year={2018},
  volume={109},
  pages={108-118}
}

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References

SHOWING 1-10 OF 158 REFERENCES

Caloric restriction in humans: impact on physiological, psychological, and behavioral outcomes.

TLDR
The first completed clinical studies that have investigated the effects of controlled, high-quality energy-restricted diets on both biomarkers of longevity and on the development of chronic diseases related to age in humans are investigated.

Manipulation of health span and function by dietary caloric restriction mimetics

TLDR
The current status of the field of CR mimetics is reviewed, with particular focus on recent developments, the most practical relevance and applicability for potential consumers, and new strategies for the future.

Interventions to Slow Aging in Humans: Are We Ready?

TLDR
There was consensus that there is sufficient evidence that aging interventions will delay and prevent disease onset for many chronic conditions of adult and old age and their potential to be safe and effective in extending human healthspan.

Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial

TLDR
CF intake reverses age-related burden of cardiovascular risk in healthy elderly, highlighting the potential of dietary flavanols to maintain cardiovascular health.

AMPK activation: a therapeutic target for type 2 diabetes?

TLDR
The regulation of the AMPK pathway and its role in type 2 diabetes, some of the known AMPK activators and their mechanisms of action, and the potential for future improvements in targeting AMPK for the treatment of T2D are reviewed.

SRT1720 improves survival and healthspan of obese mice

TLDR
It is shown that SRT1720, a synthetic compound identified for its ability to activate Sirt1 in vitro, extends both mean and maximum lifespan of adult mice fed a high-fat diet and demonstrates for the first time the feasibility of designing novel molecules that are safe and effective in promoting longevity and preventing multiple age-related diseases in mammals.

Metformin improves healthspan and lifespan in mice

TLDR
It is shown that long-term treatment with metformin starting at middle age extends healthspan and lifespan in male mice, while a higher dose (1% w/w) was toxic.
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