Interventions for rosacea: abridged updated Cochrane systematic review including GRADE assessments

@article{Zuuren2015InterventionsFR,
  title={Interventions for rosacea: abridged updated Cochrane systematic review including GRADE assessments},
  author={E. V. van Zuuren and Z. Fedorowicz},
  journal={British Journal of Dermatology},
  year={2015},
  volume={173}
}
Rosacea is a common chronic facial dermatosis. This update of our Cochrane review on interventions for rosacea summarizes the evidence, including Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group assessments, of the effects of the currently available treatments. Searches included the following: Cochrane Skin Group Specialised Register, CENTRAL in The Cochrane Library, MEDLINE, EMBASE, LILACS and the Science Citation Index, and ongoing trials registries… Expand

Paper Mentions

Interventional Clinical Trial
The aim of the study is to investigate whether brimonidine cream can reduce IPL-induced inflammation in terms of redness, swelling and pain in patients with facial vascular lesions… Expand
ConditionsTelangiectasias
InterventionDrug, Other
New developments in the treatment of rosacea – role of once-daily ivermectin cream
TLDR
In comparing topical ivermectin and metronidazole, iverMectin was more effective; this treatment modality boasted more improved quality of life, reduced lesion counts, and more favorable participant and physician assessment of disease severity. Expand
Treatment of Rosacea using acupuncture for improving the local skin microcirculation
TLDR
The results suggested that acupuncture might be an alternative therapy for facial localized rosacea through redistributing micro-circulation of blood at the localized area of effect and the overall costs of the rosace treatment may be reduced. Expand
What's new in acne and rosacea?
  • J. Keri
  • Medicine
  • Seminars in cutaneous medicine and surgery
  • 2016
TLDR
This review will discuss the most recent therapeutic options for patients with acne and rosacea, and the new topical agents - brimonidine gel and ivermectin cream - will be reviewed, with a discussion on possible rebound phenomenon from Brimonidine. Expand
Treatment of rosacea with topical ivermectin cream: a series of 34 cases.
TLDR
The use of topical ivermectin cream in the treatment of rosacea is evaluated in a series of 34 patients and the results are a reflection of the reality of clinical practice and the perception of patients of the treatment. Expand
Difference in vasoconstrictors: oxymetazoline vs. brimonidine
TLDR
Topical oxymetazoline and brimonidine are effective for the management of persistent facial erythema associated with rosacea with a few mild and localized adverse effects. Expand
Deciphering the enigma of rosacea continues…
  • J. Tan
  • Medicine
  • The British journal of dermatology
  • 2015
TLDR
This Cochrane review is a therapeutic resource for rosacea that is timely, comprehensive, credible (based on the methodology and experience of the authors) and lacks bias (absence of conflict of interest in the authorship). Expand
Rosacea: Epidemiology, pathogenesis, and treatment
TLDR
Because of the diverse presentations of rosacea, approaches to treatment must be individualized based on the disease severity, quality-of-life implications, comorbidities, trigger factors, and the patient's commitment to therapy. Expand
Understanding rosacea
  • F. Powell
  • Medicine
  • The British journal of dermatology
  • 2015
TLDR
It is revealed that blocking the action of TNF-a effectively stopped the progression of vitiligo and initiated repigmentation in almost all patients with active disease, presumably at least in part due to the stemming of cytotoxic T-cell-mediated destruction of melanocytes. Expand
Use of photodynamic therapy in the management of papulopustular rosacea
TLDR
The evidence base for the use of PDT in the papulopustular subtype of rosacea is summarized, common treatment protocols and the management of potential side effects are summarized. Expand
Incidental long term control of recalcitrant rosacea following modern radiotherapy – a case series
Rosacea is a common chronic illness with no known durable cure. We present 4 cases of incidental long-term control of recalcitrant rosacea following definitive volumetric modulated arc therapy (VMAT)Expand
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References

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Effective and evidence‐based management strategies for rosacea: summary of a Cochrane systematic review
TLDR
There was some evidence to support the effectiveness of topical metronidazole, azelaic acid and doxycycline (40 mg) in the treatment of moderate to severe rosacea, and ciclosporin 0·05% ophthalmic emulsion for ocular rosace. Expand
Azelaic acid foam 15% in the treatment of papulopustular rosacea: a randomized, double-blind, vehicle-controlled study.
TLDR
Results indicated that the new foam formulation of AzA is effective and well-tolerated in a population of patients with PPR, and allows health care providers to match the needs as well as preferences of individual patients and skin types with appropriate delivery modalities. Expand
Topical metronidazole maintains remissions of rosacea.
TLDR
In a majority of subjects studied, continued treatment with metronidazole gel alone maintains remission of moderate to severe rosacea induced by treatment with oral tetracycline and topical metronidezole gel. Expand
Topical metronidazole therapy for rosacea.
TLDR
Topical metronidazole gel therapy appears to be a safe and efficacious therapy in the treatment of moderate to severe rosacea. Expand
Efficacy and safety of azelaic acid (15%) gel as a new treatment for papulopustular rosacea: results from two vehicle-controlled, randomized phase III studies.
TLDR
The results of these 2 controlled studies demonstrate that AzA gel, used twice daily, is an efficacious, safe, and well-tolerated topical treatment for moderate, papulopustular rosacea. Expand
Randomized Placebo-controlled Trial of Metronidazole 1% Cream with Sunscreen SPF 15 in Treatment of Rosacea
TLDR
The combined topical formulation of metronidazole 1% cream with sunscreen SPF 15 was an effective, well-tolerated topical agent for the treatment of moderate to severe rosacea. Expand
Topical azelaic acid in the treatment of rosacea
TLDR
The results of a single-centre double-blind controlled contralateral split-face study of the effects of 20% azelaic acid cream in patients with rosacea showed both ‘sides’ showed a reduction in papules, pustules and erythema, although the degree of improvement was superior on the azelaing acid-treated sides. Expand
A comparison of topical azelaic acid 20% cream and topical metronidazole 0.75% cream in the treatment of patients with papulopustular rosacea.
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  • 1999
TLDR
Azelaic acid 20% cream provides an effective and safe alternative to metronidazole 0.75% cream with the added benefit of increased patient satisfaction in the treatment of patients with papulopustular rosacea. Expand
Efficacy of a novel rosacea treatment system: an investigator-blind, randomized, parallel-group study.
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  • Medicine
  • Journal of drugs in dermatology : JDD
  • 2011
TLDR
The rosacea treatment system may offer superior efficacy and tolerability to metronidazole plus the standard skin care used in this study. Expand
[Rilmenidine in rosacea: a double-blind study versus placebo].
TLDR
Rilmenidine is not efficient in reducing the number of papules and pustules but could decrease the numberof flushes, and another study including more patients and using evaluation criteria based on the vascular components of rosacea could perhaps confirm this hypothesis. Expand
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