Interventional cardiology: The importance of patient-related factors on PCI outcomes


Patient-related factors, such as comorbidities and overall severity of coronary artery disease (CAD), might be more important determinants of the outcome of percutaneous coronary intervention (PCI) with second-generation drug-eluting stents (DES) than intrinsic stent characteristics. This hypothesis has been generated by the findings of the 2-year follow-up of the Resolute All Comers trial, published in the Lancet. The Resolute All Comers trial included patients with chronic stable angina or acute coronary syndromes enrolled between April and October 2008 at 17 centres in Europe and Israel. The trial was designed to compare the efficacy of two types of new-generation stents, the Resolute® zotarolimus-eluting stent (Medtronic, Santa Rosa, CA, USA) and the Xience V® everolimus-eluting stent (Abbott Vascular, Santa Clara, CA, USA). Importantly, early trials of newgeneration DES were conducted in patient populations that are atypical of those found in clinical practice, as these studies excluded individuals with complex and/ or severe CAD and comorbidities such as diabetes mellitus and renal failure. In line with the opinion of an FDA panel, which recommended that trials of DES include a more representative range of patients, the researchers of the Resolute All Comers trial did not apply any restrictions to patient enrolment, with the exception of medication intolerance, allergies to stent components, and need for surgery within the first 6 months after PCI. Among 2,292 patients initially enrolled, 1,140 were randomly assigned to receive the zotarolimus-eluting stent and 1,152 to receive the everolimus-eluting stent. The 1-year follow-up results of the trial have been previously published. Obtaining long-term follow-up information on the outcomes of DES INTERVENTIONAL CARDIOLOGY

DOI: 10.1038/nrcardio.2011.67

Cite this paper

@article{Osrio2011InterventionalCT, title={Interventional cardiology: The importance of patient-related factors on PCI outcomes}, author={Joana Os{\'o}rio}, journal={Nature Reviews Cardiology}, year={2011}, volume={8}, pages={301-301} }