Intervention with tranilast attenuates renal pathology and albuminuria in advanced experimental diabetic nephropathy.

Abstract

BACKGROUND/AIMS Tubulointerstitial pathology with the accumulation of extracellular matrix are pathological hallmarks of diabetic nephropathy that are directly related to declining renal function. Tranilast (N-[3,4-dimethoxycinnamoyl]anthranilic acid), an inhibitor of transforming growth factor-beta (TGF-beta), used to treat hypertrophic scars has recently… (More)

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@article{Mifsud2003InterventionWT, title={Intervention with tranilast attenuates renal pathology and albuminuria in advanced experimental diabetic nephropathy.}, author={Sally A Mifsud and Darren J. Kelly and Weier Qi and Yuan Zhang and Carol A. Pollock and Jennifer Louise Wilkinson-Berka and Richard Gilbert}, journal={Nephron. Physiology}, year={2003}, volume={95 4}, pages={p83-91} }