Intervention with the aldose reductase inhibitor, tolrestat, in renal and retinal lesions of streptozotocin-diabetic rats

Abstract

The progressive increase in urinary albumin excretion, which precedes the development of diabetic nephropathy, can be prevented in diabetic rats if the aldose reductase inhibitor, tolrestat, is administered at the initiation and throughout the duration of hyperglycaemia. We therefore determined the ability of tolrestat to intervene in the further… (More)
DOI: 10.1007/BF00401513

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@article{McCaleb1991InterventionWT, title={Intervention with the aldose reductase inhibitor, tolrestat, in renal and retinal lesions of streptozotocin-diabetic rats}, author={Michael L. McCaleb and Margaret L. McKean and Thomas C. Hohman and Nora M V Laver and W. Gerald Robison}, journal={Diabetologia}, year={1991}, volume={34}, pages={695-701} }