Intervention with exercise restores motor deficits but not nigrostriatal loss in a progressive MPTP mouse model of Parkinson's disease.

@article{Sconce2015InterventionWE,
  title={Intervention with exercise restores motor deficits but not nigrostriatal loss in a progressive MPTP mouse model of Parkinson's disease.},
  author={Michelle D. Sconce and Madeline J. Churchill and Richard E. Greene and Charles K. Meshul},
  journal={Neuroscience},
  year={2015},
  volume={299},
  pages={156-74}
}
Many studies have investigated exercise therapy in Parkinson's disease (PD) and have shown benefits in improving motor deficits. However, exercise does not slow down the progression of the disease or induce the revival of lost nigrostriatal neurons. To examine the dichotomy of behavioral improvement without the slowing or recovery of dopaminergic cell or terminal loss, we tested exercise therapy in an intervention paradigm where voluntary running wheels were installed half-way through our… CONTINUE READING