Intervention of death-associated protein kinase 1-p53 interaction exerts the therapeutic effects against stroke.

@article{Wang2014InterventionOD,
  title={Intervention of death-associated protein kinase 1-p53 interaction exerts the therapeutic effects against stroke.},
  author={Xiaoxi Wang and Lei Pei and Honglin Yan and Zhongping Wang and Na Wei and Shan Wang and Xin Yang and Q Tian and Youming Lu},
  journal={Stroke},
  year={2014},
  volume={45 10},
  pages={
          3089-91
        }
}
BACKGROUND AND PURPOSE Death-associated protein kinase 1 (DAPK1) interacts with the tumor suppressor gene p53 via a direct binding of a death domain of DAPK1 to a DNA-binding motif (DM) of p53 (p53DM) and converges multiple cell death pathways in stroke. The goals of this study are to determine whether disruption of DAPK1-p53 interaction is therapeutically effective against stroke. METHODS We synthesized a membrane-permeable p53DM peptide (Tat-p53DM) and tested the therapeutic effects of Tat… CONTINUE READING

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