Intervention of Bro1 in pH-responsive Rim20 localization in Saccharomyces cerevisiae.

  title={Intervention of Bro1 in pH-responsive Rim20 localization in Saccharomyces cerevisiae.},
  author={Jacob H. Boysen and Shoba Subramanian and Aaron P. Mitchell},
  journal={Eukaryotic cell},
  volume={9 4},
Yeast cells contain two Bro1 domain proteins: Bro1, which is required for endosomal trafficking, and Rim20, which is required for the response to the external pH via the Rim101 pathway. Rim20 associates with endosomal structures under alkaline growth conditions, when it promotes activation of Rim101 through proteolytic cleavage. We report here that the pH-dependent localization of Rim20 is contingent on the amount of Bro1 in the cell. Cells that lack Bro1 have increased endosomal Rim20-green… CONTINUE READING
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