Intervention in a family of Boolean networks

  title={Intervention in a family of Boolean networks},
  author={Ashish Choudhury and Aniruddha Datta and Michael L. Bittner and Edward R. Dougherty},
  volume={22 2},
MOTIVATION Intervention in a gene regulatory network is used to avoid undesirable states, such as those associated with a disease. Several types of intervention have been studied in the framework of a probabilistic Boolean network (PBN), which is a collection of Boolean networks in which the gene state vector transitions according to the rules of one of the constituent networks and where network choice is governed by a selection distribution. The theory of automatic control has been applied to… CONTINUE READING
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