Intervention at the level of the neuroendocrine-immune axis and postoperative pneumonia rate in long-term alcoholics.

@article{Spies2006InterventionAT,
  title={Intervention at the level of the neuroendocrine-immune axis and postoperative pneumonia rate in long-term alcoholics.},
  author={Claudia D Spies and Verena Eggers and Gyongyi Szabo and Alexandra Lau and Vera von Dossow and Helge Schoenfeld and Hilke Althoff and Katrin Hegenscheid and Birgit Bohm and Torsten Hans Schroeder and Sebastian Pfeiffer and Sabine Ziemer and Christian Paschen and Martin Klein and Christian Marks and Peter Miller and Michael Sander and Klaus-D. Wernecke and Evelin Achterberg and Udo X. Kaisers and H P Volk},
  journal={American journal of respiratory and critical care medicine},
  year={2006},
  volume={174 4},
  pages={408-14}
}
RATIONALE Postoperative pneumonia is three to four times more frequent in patients with alcohol use disorders followed by prolonged intensive care unit (ICU) stay. Long-term alcohol use leads to an altered perioperative hypothalamus-pituitary-adrenal (HPA) axis and immunity. OBJECTIVES The aim of this study was to evaluate HPA intervention with low-dose ethanol, morphine, or ketoconazole on the neuroendocrine-immune axis and development of postoperative pneumonia in long-term alcoholic… CONTINUE READING

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