Intervening Sequences of Regularly Spaced Prokaryotic Repeats Derive from Foreign Genetic Elements

@article{Mojica2004InterveningSO,
  title={Intervening Sequences of Regularly Spaced Prokaryotic Repeats Derive from Foreign Genetic Elements},
  author={F. J. Mojica and C{\'e}sar D{\'i}ez-Villase{\~n}or and J. Garc{\'i}a-Mart{\'i}nez and E. Soria},
  journal={Journal of Molecular Evolution},
  year={2004},
  volume={60},
  pages={174-182}
}
Prokaryotes contain short DNA repeats known as CRISPR, recognizable by the regular spacing existing between the recurring units. They represent the most widely distributed family of repeats among prokaryotic genomes, suggesting a biological function. The origin of the intervening sequences, at present unknown, could provide clues about their biological activities. Here we show that CRISPR spacers derive from preexisting sequences, either chromosomal or within transmissible genetic elements such… Expand
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  • Biology, Medicine
  • Genes & Genomics
  • 2018
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