Interval training normalizes cardiomyocyte function, diastolic Ca2+ control, and SR Ca2+ release synchronicity in a mouse model of diabetic cardiomyopathy.

@article{Stlen2009IntervalTN,
  title={Interval training normalizes cardiomyocyte function, diastolic Ca2+ control, and SR Ca2+ release synchronicity in a mouse model of diabetic cardiomyopathy.},
  author={Tomas O. St\olen and Morten Andre H\oydal and Ole Johan Kemi and Daniele Catalucci and Marcello Ceci and Ellen Aasum and Terje Larsen and Natale Rolim and Gianluigi Condorelli and Godfrey L. Smith and Ulrik Wisl\off},
  journal={Circulation research},
  year={2009},
  volume={105 6},
  pages={527-36}
}
RATIONALE In the present study we explored the mechanisms behind excitation-contraction (EC) coupling defects in cardiomyocytes from mice with type-2 diabetes (db/db). OBJECTIVE We determined whether 13 weeks of aerobic interval training could restore cardiomyocyte Ca(2+) cycling and EC coupling. METHODS AND RESULTS Reduced contractility in cardiomyocytes isolated from sedentary db/db was associated with increased diastolic sarcoplasmic reticulum (SR)-Ca(2+) leak, reduced synchrony of Ca(2… CONTINUE READING
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