Interval mapping methods for detecting QTL affecting survival and time-to-event phenotypes.

@article{Moreno2005IntervalMM,
  title={Interval mapping methods for detecting QTL affecting survival and time-to-event phenotypes.},
  author={Carole R Moreno and J. M. Elsen and Pascale Le Roy and V. Ducrocq},
  journal={Genetical research},
  year={2005},
  volume={85 2},
  pages={139-49}
}
Quantitative trait loci (QTL) are usually searched for using classical interval mapping methods which assume that the trait of interest follows a normal distribution. However, these methods cannot take into account features of most survival data such as a non-normal distribution and the presence of censored data. We propose two new QTL detection approaches which allow the consideration of censored data. One interval mapping method uses a Weibull model (W), which is popular in parametrical… CONTINUE READING

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