Interval-dependent effects of small antiarrhythmic drugs on excitability of guinea-pig myocardium.

@article{Courtney1980IntervaldependentEO,
  title={Interval-dependent effects of small antiarrhythmic drugs on excitability of guinea-pig myocardium.},
  author={Kenneth R. Courtney},
  journal={Journal of molecular and cellular cardiology},
  year={1980},
  volume={12 11},
  pages={
          1273-86
        }
}
Abstract Myocardial depressant actions of seven antiarrhythmic drugs have been studied in vitro in guinea-pig papillary muscle preparations, using upstroke velocity of action potentials as a measure of myocardial excitability. Drug-induced depression of upstroke velocity is shown to be greater after an action potential than before; upstroke velocity recovers from such use-induced depression with widely varying half-times ranging from a tenth of a second to several seconds, depending upon the… CONTINUE READING
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