Interval Timing Is Preserved Despite Circadian Desynchrony in Rats: Constant Light and Heavy Water Studies

  title={Interval Timing Is Preserved Despite Circadian Desynchrony in Rats: Constant Light and Heavy Water Studies},
  author={Christian C. Petersen and R. Mistlberger},
  journal={Journal of Biological Rhythms},
  pages={295 - 308}
The mechanisms that enable mammals to time events that recur at 24-h intervals (circadian timing) and at arbitrary intervals in the seconds-to-minutes range (interval timing) are thought to be distinct at the computational and neurobiological levels. Recent evidence that disruption of circadian rhythmicity by constant light (LL) abolishes interval timing in mice challenges this assumption and suggests a critical role for circadian clocks in short interval timing. We sought to confirm and extend… Expand
Circadian modulation of motivation in mice
The results indicate that motivation for food reward is regulated in a circadian manner, independent of the nutritional status and the nature of the reward, and that this rhythmic modulation is not affected by aging. Expand
Interval timing is disrupted in female 5xFAD mice: An indication of altered memory processes
It is found that the time of maximal reward expectancy (peak time) of the 5xFAD mice was significantly earlier than that of the wild‐type (WT) controls with no differences in other indices of timing performance. Expand
The Times of Our Lives: Interaction Among Different Biological Periodicities
This work presents and discusses a model that accounts for the circadian regulation of both ultradian and infradian cycles, and shows two clear examples of interaction between the circadian clock and the seasonal regulation of the Hypothalamic-Pituitary-Thyroid (HPT) axis. Expand
Subjective time estimation in Antarctica: The impact of extreme environments and isolation on a time production task
An impact of isolation on morning performances and an effect of the polar night on evening measures are suggested, shedding some light on the use of interval timing as a cognitive test to assess performance in extreme environments. Expand


Circadian modulation of interval timing in mice
The results indicate that short-time estimation in animals subjected to circadian desynchronizations was affected and was modulated by the circadian clock. Expand
Interval timing in mice does not rely upon the circadian pacemaker
Results show that the accurate measurement of 10 s requires neither a functioning circadian pacemaker nor entrained behavioural rhythmicity, and indirectly involved in measurement of a briefer interval. Expand
Involvement of dopamine signaling in the circadian modulation of interval timing
It is suggested that the lack of DA rhythmicity in the striatum under LL – probably regulated by Per2 – could be responsible for impaired performance in the timing task, adding further support to the notion that circadian and interval timing share some common processes, interacting at the level of the dopaminergic system. Expand
Circadian pitfalls in experimental designs employing food restriction
Most physiological and behavioral processes exhibit prominent circadian (24-h) rhythms that maintain a stable phase relation to daily light-dark cycles by means of entrainment. These rhythms canExpand
Circadian variations in time perception in rats
The hypothesis that time perception is determined by an internal clock's rate, which is sensitive to physiological circadian changes was examined. This hypothesis suggests that when body temperatureExpand
Food-entrained circadian rhythms in rats are insensitive to deuterium oxide
D(2)O may have utility as a screening test to identify putative food-entrainable pacemakers from among those central and peripheral tissues that can express circadian oscillations of clock genes independent of the SCN. Expand
Circadian Mechanisms of Food Anticipatory Rhythms in Rats Fed Once or Twice Daily: Clock Gene and Endocrine Correlates
The absence of rhythmicity at the tissue level in brain regions from rats anticipating 2 daily meals support behavioral evidence that circadian clock cells in these tissues may reorganize into two populations coupled to different meals. Expand
Melatonin Modulates Interval Timing in Rats: Effect of Pinealectomy
Interval timing is a complex cognitive process that involves the estimation of time within the seconds-to-minutes range. This temporal processing depends on cortico-striatal interactions, as well asExpand
Variable Restricted Feeding Disrupts the Daily Oscillations of Period2 Expression in the Limbic Forebrain and Dorsal Striatum in Rats
Contrary to the synchronizing effects of predictable restricted feeding, VRF blunts the daily corticosterone rhythm and disrupts daily rhythms of PER2 expression in a region-specific and mealtime-dependent manner. Expand
Effects of scheduled food and water access on circadian rhythms of hamsters in constant light, dark, and light:dark
The properties of food anticipation and entrainment under the three lighting conditions support a model of the hamster circadian system that incorporates separate but strongly coupled food/water- and light-entrainable pacemakers. Expand