Intertissue Differences for the Role of Glutamate Dehydrogenase in Metabolism

  title={Intertissue Differences for the Role of Glutamate Dehydrogenase in Metabolism},
  author={Jason R Treberg and Sheena Banh and Umesh Kumar Pandey and Dirk Weihrauch},
  journal={Neurochemical Research},
The enzyme glutamate dehydrogenase (GDH) plays an important role in integrating mitochondrial metabolism of amino acids and ammonia. Glutamate may function as a respiratory substrate in the oxidative deamination direction of GDH, which also yields α-ketoglutarate. In the reductive amination direction GDH produces glutamate, which can then be used for other cellular needs such as amino acid synthesis via transamination. The production or removal of ammonia by GDH is also an important consequence… CONTINUE READING

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