Interstrain variation in the human cytomegalovirus DNA polymerase sequence and its effect on genotypic diagnosis of antiviral drug resistance. Adult AIDS Clinical Trials Group CMV Laboratories.

@article{Chou1999InterstrainVI,
  title={Interstrain variation in the human cytomegalovirus DNA polymerase sequence and its effect on genotypic diagnosis of antiviral drug resistance. Adult AIDS Clinical Trials Group CMV Laboratories.},
  author={Sunwen Chou and Nell S. Lurain and Adriana Weinberg and G Y Cai and P. L. Sharma and Clyde S. Crumpacker},
  journal={Antimicrobial agents and chemotherapy},
  year={1999},
  volume={43 6},
  pages={1500-2}
}
The polymerase (pol) coding sequence was determined for 40 independent clinical cytomegalovirus isolates sensitive to ganciclovir and foscarnet. Sequence alignments showed >98% interstrain homology and amino acid variation in only 4% of the 1, 237 codons. Almost all variation occurred outside of conserved functional domains where resistance mutations have… CONTINUE READING