Interstitial vascular rarefaction and reduced VEGF-A expression in human diabetic nephropathy.

@article{Lindenmeyer2007InterstitialVR,
  title={Interstitial vascular rarefaction and reduced VEGF-A expression in human diabetic nephropathy.},
  author={Maja Tamara Lindenmeyer and Matthias Kretzler and Anissa Boucherot and Silvia Berra and Yoshinari Yasuda and Anna Henger and Felix Eichinger and Stefanie Gaiser and Holger Schmid and Maria P Rastaldi and Robert Schrier and Detlef Schloendorff and Clemens David Cohen},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2007},
  volume={18 6},
  pages={1765-76}
}
Diabetic nephropathy (DN) is a frequent complication in patients with diabetes. Although the majority of DN models and human studies have focused on glomeruli, tubulointerstitial damage is a major feature of DN and an important predictor of renal dysfunction. This study sought to investigate molecular markers of pathogenic pathways in the renal interstitium of patients with DN. Microdissected tubulointerstitial compartments from biopsies with established DN and control kidneys were subjected to… CONTINUE READING