Interstitial pathomechanisms underlying progressive tubulointerstitial damage.

  title={Interstitial pathomechanisms underlying progressive tubulointerstitial damage.},
  author={Frank M Strutz and Gerhard A. M{\"u}ller},
  journal={Kidney & blood pressure research},
  volume={22 1-2},
Progressive renal disease poses an increasing problem for the medical community. Though the causes of end-stage renal failure are multiple, the histologic pictures of chronic renal disease are remarkably similar being characterized by interstitial infiltration, fibrosis, tubular atrophy and dilatation. This similarity points to a final common pathway. In addition, renal disease often progresses despite elimination or amelioration of the inciting stimulus. This review deals with the… CONTINUE READING