Interstitial insertion of AF10 into the ALL1 gene in a case of infant acute lymphoblastic leukemia.

@article{Angioni1998InterstitialIO,
  title={Interstitial insertion of AF10 into the ALL1 gene in a case of infant acute lymphoblastic leukemia.},
  author={Adriano Angioni and Roberta La Starza and Cristina Mecucci and Teresa Sprovieri and Caterina Matteucci and Giulio de Rossi and P Balloni and Giuseppe Cimino},
  journal={Cancer genetics and cytogenetics},
  year={1998},
  volume={107 2},
  pages={107-10}
}
The ALL1 gene at 11q23 is a promiscuous gene participating in chromosomal abnormalities of acute leukemias with 1 of over 30 potential partner genes. Among these, the AF10 gene at band 10p12 has been recently cloned and characterized. Acute leukemias with the ALL1/AF10 chimeric gene frequently show heterogeneity in the breakpoints on 10p, as well as complex insertion (10;11) as a result of complex molecular mechanisms leading to the ALL1/AF10 fusion. In this context, we report the first… CONTINUE READING

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