Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer.

  title={Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer.},
  author={Helge Wiig and Melody A. Swartz},
  journal={Physiological reviews},
  volume={92 3},
The interstitium describes the fluid, proteins, solutes, and the extracellular matrix (ECM) that comprise the cellular microenvironment in tissues. Its alterations are fundamental to changes in cell function in inflammation, pathogenesis, and cancer. Interstitial fluid (IF) is created by transcapillary filtration and cleared by lymphatic vessels. Herein we discuss the biophysical, biomechanical, and functional implications of IF in normal and pathological tissue states from both fluid balance… 

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