Interstitial continuous infusion therapy in a malignant glioma model in rats

Abstract

Local direct delivery of chemotherapeutic agents for the treatment of brain tumors is an area of focus in the development of new therapeutic paradigms. These techniques need improvement, especially in terms of drug retention in brain tissue. In this study, we used a rat glioma model to examine carboplatin distribution, as measured by platinum penetration… (More)
DOI: 10.1007/s00381-008-0805-3

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